スペインにおけるSARS-CoV-2の流行 (ENE-COVID): 全国規模の集団ベースの血清疫学研究
Marina Pollán1, Beatriz Pérez-Gómez1, Roberto Pastor-Barriuso1
1National Centre for Epidemiology, Institute of Health Carlos III, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Institute of Health Carlos III, Madrid, Spain.
Lancet (London, England)
|July 10, 2020
まとめ
この全国的な調査は,スペインのほとんどの
科学分野:
- 流行病学
- 感染症
- 公衆衛生
背景:
- スペインは,COVID-19症例の高い負担を経験しました.
- 血清学的調査は,無症状の感染と検査へのアクセスが限られているため,疫病の拡散を理解するために不可欠です.
- SARS-CoV-2の血清発生率を評価することは,公衆衛生の計画に不可欠です.
研究 の 目的:
- スペインにおけるSARS-CoV-2感染の全国的および地域的感染率を推定する.
- スペインの人口におけるCOVID-19の流行の範囲を理解するためです.
- 公衆衛生の戦略と介入の情報提供
主な方法:
- 全国の人口ベースの研究で,35,883世帯と61,075人の参加者が参加した.
- 2段階のランダムサンプリングで,州と自治体の大きさによって層分かれています.
- データ収集には,症状と危険因子に関するアンケート,診療所での抗体検査,IgG抗体の化学発光微粒子の免疫検査が含まれていました. 血清分布は非応答バイアスに調整された.
主要な成果:
- 全体の血清発生率は3. 7%から6. 2%に及び,地域によって異なる (例えば,マドリード周辺では10%以上,沿岸地域では3%未満).
- 10歳未満の子どもでは血清発生率が低く,性別による差異は認められなかった.
- 陽性患者の約3分の1は無症状であり,PCRで確認されたほとんどの症例は検出可能な抗体を示した.
結論:
- スペイン人の大半は 感染頻度が高い地域でも 血清陰性でした
- COVID-19感染の有意な部分は無症状であり,症状に基づく検出の限界を強調しています.
- この結果は,SARS-CoV-2の伝染を制御するための公衆衛生対策の継続的な必要性を強調しています.
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