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Updated: Dec 15, 2025

Subcutaneous Administration of Muscarinic Antagonists and Triple-Immunostaining of the Levator Auris Longus Muscle in Mice
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Subcutaneous Administration of Muscarinic Antagonists and Triple-Immunostaining of the Levator Auris Longus Muscle in Mice

Published on: September 8, 2011

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M1マスカリン受容体毒素複合体の構造と選択性工学

Shoji Maeda1, Jun Xu2, Francois Marie N Kadji3

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. shojim@stanford.edu kobilka@stanford.edu.

Science (New York, N.Y.)
|July 11, 2020
PubMed
まとめ

マスカリン毒素 (MTs) と呼ばれる蛇の毒素は,マスカリンアセチルコリン受容体 (MAChR) に結合する. 研究者らは受容体に結合する毒素の構造を決定し 特定のサブタイプを標的にし 新しい毒素の変種を設計することを可能にしました

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Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
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Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
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Competitive antagonists prevent acetylcholine from binding to its receptor, inhibiting membrane depolarization. Without conformational changes or intrinsic...
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