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Updated: Dec 14, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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誘発性酵素は,乳酸塩Aへの経路で基板レベルで協力する

Alexander A Vinogradov1, Morito Shimomura, Naokazu Kano2

  • 1Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|July 16, 2020
PubMed
まとめ

この研究では 5つの酵素が連携して 複雑なペプチドであるラクタゾールAを 作り出すことを明らかにしました 酵素の協力により,正しいチオペプチド産物が形成され,自然産物の生物合成の理解が進みます.

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