レジオおよびエナチオセレクティブのアリルC-Hアミデーションのための平面キラルロジウムインデニル触媒の設計
Caitlin M B Farr1, Amaan M Kazerouni1, Bohyun Park2,3
1Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Journal of the American Chemical Society
|July 16, 2020
まとめ
研究者は,エナチオセレクティブC-H機能化のための新しい平面性インデニルロジウム複合体を開発した. この触媒は,オレフィンの非対称性アリルC-Hアミダ化を可能にし,高い選択性を持つ有価なエナンチオ濃縮製品を生成します.
科学分野:
- 有機金属化学
- 非対称な触媒
- C-H 機能化
背景:
- グループIXのCpとCp*触媒は,エナチオセレクティブ反応について知られている.
- 既存のエナチオコントロール戦略は,リガンド設計におけるステリックブロックに依存しています.
研究 の 目的:
- エナチオセレクティブC-H機能化のための新しい平面性インデニルロジウム複合体を開発する.
- リガンド設計における電子非対称性を探求し,エナチオ制御を強化する.
主な方法:
- 新しい平面性インデニルロジウム複合体の合成
- 活性化されていないオレフィンを用いた非対称性アリルC-Hアミデーションの触媒化.
- 反応メカニズムを解明するための計算研究.
主要な成果:
- 新しい複合体は非対称なアリルC-Hアミデーションを効率的に触媒化する.
- 様々なアリルアミド製品では,高い収穫量と優れた地域およびエナチオ選択性が得られた.
- 計算分析により,C−H割れが速度とエナンチオを決定するステップであることが示された.
結論:
- 開発されたインデニルロジウム複合体は,エナチオセレクティブC-H機能化のための新しいプラットフォームを提供します.
- リガンド設計における電子非対称性は,エナチオ選択性を制御するための実行可能な戦略である.
- 触媒は有価なエナチオ濃縮アリルアミドへのアクセスを提供します.
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