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Updated: Dec 14, 2025

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
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Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

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遺伝パターン,不律性リスク,およびCASQ2-カテコラミナージック多型心室性タキカルディアの基礎的なメカニズムの国際多中心評価

Kevin Ng1,2, Erron W Titus3, Krystien V Lieve4,5

  • 1Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, ON, Canada (K.N., J.W., A.S.T., A.C.S., J.M., J.D.R.).

Circulation
|July 23, 2020
PubMed
まとめ

カルセクエストリン-2 (CASQ2) の遺伝的変異は,カテコアミナージック多型室動脈性急性心臓発作 (CPVT) を引き起こします. この研究では,異体性CASQ2変種もCPVTを引き起こすことが示され,これらの個体に対する臨床スクリーニングが必要である.

キーワード:
心臓発作カテコアミナージックポリモルフィック Ventricular タキカルディア突然の心臓発作による死亡遺伝学

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