脂肪組織の交感内置を調節するレプチン-BDNF経路
Putianqi Wang1, Ken H Loh2, Michelle Wu1
1Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
Nature
|July 24, 2020
まとめ
レプチンは脂肪組織を調節する
科学分野:
- メタボリック障害
- 神経内分泌学
- 脂肪組織生物学
背景:
- レプチン遺伝子の変異は 肥満と脂肪組織機能の障害を引き起こします
- 交感神経系は熱生成と脂質分解のような脂肪組織機能を制御する.
- 交感機能に対するレプチンの作用のメカニズムは不明である.
研究 の 目的:
- 脂肪組織の交感性内置の調節におけるレプチンの役割を調査する.
- 脂肪組織の交感機能に対するレプチンの作用を媒介する神経経路を明らかにする.
- レプチンのエネルギーホメオスタシスの調節に関与する下垂体核を特定する.
主な方法:
- 肥満マウスとダイエットによる肥満マウスを研究した.
- 慢性的なレプチンの投与
- 特定のニューロン集団におけるレプチン受容体とBDNF遺伝子の遺伝子操作を利用した.
- 白色と茶色の脂肪組織の同情内置を評価した.
主要な成果:
- レプチンの欠乏は脂肪組織における交感内置を減少させる.
- レプチンの治療は,交感内置を回復し,機能的欠陥を修正します.
- レプチンの作用は,下垂体弧状核ニューロン (AgRPとPOMC) とパラベントリキュラー核 (BDNF) によって媒介されます.
- レプチン受容体またはBDNFの遺伝的消去は,レプチンの内置作用を損なう.
結論:
- レプチンシグナル伝達は脂肪組織の交感内膜の可塑性を制御する.
- 上から下への神経経路は レプチンの作用に不可欠です
- この経路は エネルギーホメオスタシスの維持に不可欠です
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