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Updated: Dec 14, 2025

Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization
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イタコナートは,ラブGTPアースのセル・オートノムホスト防御経路のエフェクタである

Meixin Chen1, Hui Sun1, Maikel Boot1

  • 1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA.

Science (New York, N.Y.)
|July 25, 2020
PubMed
まとめ

グアノシントライフォスファターゼ (GTPase) Rab32タンパク質とアコニテットデカルボキシラーゼ1 (IRG1) は,サルモネラ複製を制限するために一緒に作用する. 抗菌代謝物質であるイタコナートは,Rab32によって病原体バキュールに放出されます.

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Rab Proteins

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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