ENCODEに関する展望

, Michael P Snyder^1,2, Thomas R Gingeras³

¹Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA. mpsnyder@stanford.edu.

Nature

|July 31, 2020

まとめ

DNA要素の百科事典 (ENCODE) プロジェクトは,ヒトとマウスのゲノムをマッピングし,遺伝子調節研究のための候補シス調節要素 (cCREs) のような機能的要素を特定します.

科学分野:

ゲノミクス
分子生物学
バイオ情報学

背景:

DNA要素の百科事典 (ENCODE) プロジェクトは,ヒトゲノムの機能的要素をマッピングすることを目的としています.
機能的要素には遺伝子,調節領域,およびトランスクリプトイソフォームが含まれます.

研究の目的:

ヒトとマウスのゲノムに含まれる機能的要素の包括的な地図を作成する.
遺伝子調節に関与する候補シス調節要素 (cCREs) を特定する.

主な方法:

ゲノムデータを用いて遺伝子,規制領域,そしてトランスクリプトの同型を特定した.
遺伝子調節に関連した生化学的なマークを注釈するテクニックを適用します.
ENCODEの適用範囲をモデル生物,特にマウスに拡大しました.

主要な成果:

ヒトゲノムに関する100万の cCRE アノテーションを生成した.
マウスのゲノムに300,000以上の cCRE アノテーションを生成した.
ゲノム機能を理解する上で科学界にとって貴重な資源を確立した.

結論:

ENCODEプロジェクトは多くの機能的なゲノム要素をマッピングすることに成功しました
生成されたcCREアノテーションは,遺伝子調節に関する重要な洞察を提供します.
このリソースは,ゲノミクスと分子生物学における進行中の研究に大きく役立つ.

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