関連する実験動画

Updated: Dec 13, 2025

CIRCLE-Seq for Interrogation of Off-Target Gene Editing
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CIRCLE-Seq for Interrogation of Off-Target Gene Editing

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バクテリアのアルゴナウト核酵素によるDNA標的と干渉

Anton Kuzmenko1,2, Anastasiya Oguienko3, Daria Esyunina3

  • 1Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia. dr.ant.kuz@gmail.com.

Nature
|July 31, 2020
PubMed
まとめ

この研究では,バクテリアのアルゴナウトタンパク質 (Ago) が外来DNAから防御するためにDNAガイドを使用し,プラズミッドとファージを標的にすることを明らかにしました. アゴとプロカリオットの防御システムを結びつける ガイド生成とDNA分解のメカニズムを明らかにした

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