多数の肝細胞の肝細胞時計と栄養制御の時間物理学
Dongyin Guan1,2, Ying Xiong1,2, Trang Minh Trinh1,2
1Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Science (New York, N.Y.)
|August 1, 2020
まとめ
肝細胞の周辺の分子の時計は 日々のリズムと代謝を調節します REV-ERBα/βを削除すると,これらのリズムが乱され,肝臓機能と細胞伝達に影響を与え,栄養信号の調整における肝細胞時計の役割を強調します.
科学分野:
- クロノバイオロジー
- 分子生物学
- 代謝の調節
背景:
- ほとんどの体細胞には 分子時計がありますが 周辺の時計 特に肝臓の役割は不明です
- 肝臓のリズムを 理解することは 代謝の健康に不可欠です
研究 の 目的:
- 生理学的リズム性のために肝細胞 (肝細胞) の分子時計の必要性を調査する.
- 肝臓の遺伝子発現と代謝に REV-ERBα と REV-ERBβ 欠損が及ぼす影響を決定する.
主な方法:
- 成人マウス肝細胞におけるREV- ERBαとREV- ERBβの除去
- 肝臓の遺伝子発現とデノボリポゲネシスの昼間リズム分析
- 様々な肝臓細胞のトランスクリプトミクとメタボロミクの変化の評価
- 時計の階層を研究するために 食料の利用可能性を操作する.
主要な成果:
- 肝細胞のREV- ERBα/ βの欠失により,特定の肝臓遺伝子の昼間リズムが乱され,新たな脂質生成が起こりました.
- 肝細胞のREV- ERBの喪失により,複数の肝細胞のリズムトランスクリプトームとメタボロームが変化した.
- 細胞内在の肝細胞の時計と環境からの餌のシグナルとの間の階層が示された.
結論:
- 肝細胞の分子時計は 栄養信号と細胞間通信の調整に 重要な役割を果たします
- これらの発見は,リズム的な代謝と肝臓の生理学を調節する肝細胞時計の新しい機能を明らかにしています.
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