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Updated: Dec 13, 2025

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人間の胎児のマイクログリアは,発達初期に恒常的な免疫感知特性を獲得する

L Kracht1, M Borggrewe1, S Eskandar1,2

  • 1Department of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Science (New York, N.Y.)
|August 1, 2020
PubMed
まとめ

ヒトの胎児のマイクログリアは 妊娠初期に免疫感知機能を発達させる. この成熟プロセスは,妊娠中に発達中の中枢神経系の環境要因に対する脆弱性を高めます.

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Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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