長期のビタミンD3補給とプラセボのうつ病リスクや臨床的に重要なうつ病症状,および気分スコアの変化に対する影響:ランダム化臨床試験

Olivia I Okereke^1,2,3, Charles F Reynolds⁴, David Mischoulon¹

¹Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston.

JAMA

|August 5, 2020

まとめ

ビタミンD3のサプリメントは,うつ病のリスクを有意に低下させず,50歳以上の成人の気分スコアを改善しませんでした. この結果からビタミンD3はこの集団におけるうつ病の予防に効果的ではないことがわかります

科学分野:

ゲロントロジー
栄養精神科
臨床試験

背景:

低濃度の25-ヒドロキシビタミンDは,後年におけるうつ病のリスク増加と関連しています.
大量のビタミンD3をうつ病の予防のために研究する大規模な長期試験は限られている.

研究の目的:

高齢者のうつ病予防と気分改善におけるビタミンD3補給の有効性を評価する.

主な方法:

VITAL- DEPのランダム化臨床試験には,50歳以上の18000人以上の成人が参加しました.
参加者は,ビタミンD3を1日2000IUまたはプラセボを平均5. 3年間摂取した.
鬱病リスクと気分スコア (PHQ- 8) は,主なアウトカム指標でした.

主要な成果:

プラセボと比較して,ビタミンD3の補給は,うつ病の発生率や再発に統計的に有意な違いを示さなかった.
ビタミンD3とプラセボのグループでは,気分スコアに有意な改善は見られなかった.
うつ病または臨床的に重要なうつ症状の危険比率は0. 97 (95%CI,0. 87から1. 09) であった.

結論:

ビタミンD3のサプリメントは,50歳以上の成人のうつ病のリスクを有意に軽減したり,気分を改善したりしませんでした.
この研究では,この集団におけるうつ病の予防のためにビタミンD3の使用は支持されていません.
気分障害におけるビタミンDの役割に影響を与える他の要因をさらに調査するかもしれない.

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