恐ろしい 出来事 の 悲惨 な 終わり
Raluca Pascalau1, Rejji Kuruvilla1
1Department of Biology, Johns Hopkins University, 3400 N. Charles St., 227 Mudd Hall, Baltimore, MD 21218, USA.
Cell
|August 9, 2020
まとめ
交感神経は筋肉に繋がり 毛皮の幹細胞とシナプスのような接点を形成します この相互作用は,特に寒い環境への反応として,髪の再生を促進します.
科学分野:
- 皮膚科
- 神経科学
- 再生医療
背景:
- 皮のピロエレクションは,交感神経のユニット,アレクターピリ筋,毛皮を含む.
- ピロエレクション以外の生理学的反応におけるこの単位の正確な役割は完全に理解されていません.
研究 の 目的:
- 交感神経,筋,毛皮の機能的なつながりを調べる
- これらの神経筋肉構造が 毛胞の幹細胞活動や 髪の再生に 影響するかどうかを判断する.
主な方法:
- 皮膚モデルで神経-筋肉-毛皮の相互作用を視覚化するために,先進的なイメージング技術を使用しました.
- 観察された結合に関与するシグナル伝達経路を特定するために遺伝的および分子分析を使用した.
- 寒さへの曝露と神経・筋肉・毛の標的の操作後の毛の再生能力の評価
主要な成果:
- 交感神経末端と毛皮の幹細胞の間の"シナプスのような"接点が特定され,アレクターピリ筋によって媒介される.
- このユニットの冷凍誘発による活性化が 毛皮幹細胞の増殖と毛糸の生成を促進することを示した.
- ニューロ・筋肉の信号で 髪の再生を促す 新しいメカニズムを紹介した
結論:
- 交感神経とアレクター・ピリ筋は,毛胞幹細胞を直接調節する機能的な神経筋肉単位を形成する.
- この新発見の経路は 寒い刺激に反応して 髪の再生を促進する上で重要な役割を果たします
- 髪の毛の成長を促進し,脱毛状態を治療するための潜在的な治療目標を強調しています.
関連する概念動画
Accessory Structures of the Skin: Hair and Hair Follicles
4.0K
Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
4.0K
Robbers Cave
14.6K
During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension...
14.6K
Decreased Body Temperature
875
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
875
Accessory Structures of the Skin: Hair Growth and Types
2.1K
Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
2.1K
Thermoregulation
2.1K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
2.1K
Increased Body Temperature
6.3K
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
6.3K


