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Updated: Dec 12, 2025

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
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Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events

Published on: May 13, 2019

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SARS-CoV-2複製-転写複合体におけるヘリカーゼ-ポリメラーゼ結合の構造的基礎

James Chen1, Brandon Malone1, Eliza Llewellyn1

  • 1Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.

Cell
|August 14, 2020
PubMed
まとめ

研究者は,nsp13ヘリケーズでSARS-CoV-2のRNA依存RNAポリメラーゼ (RdRp) コンプレクスを視覚化しました. この構造的な洞察は,ヘリケーズのRdRpとの相互作用を明らかにし,ウイルスの複製とCOVID-19薬の開発に不可欠です.

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