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Updated: Dec 12, 2025

Assaying the Kinase Activity of LRRK2 in vitro
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Assaying the Kinase Activity of LRRK2 in vitro

Published on: January 18, 2012

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パーキンソン病に関連したLRRK2の局所構造

Reika Watanabe1, Robert Buschauer1, Jan Böhning1

  • 1Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

Cell
|August 14, 2020
PubMed
まとめ

レウシンに富んだリピートキナーゼ2 (LRRK2) の病原性突然変異が家族性パーキンソン病を引き起こす. 研究者は,マイクロチューブルの周りのLRRK2のダブルヘリックス構造を明らかにし,疾患メカニズムへの洞察を提供しました.

キーワード:
パーキンソン病相関光と電子顕微鏡冷凍電子トモグラフィー統合モデリングキナーゼレウシンに富んだリピートキナーゼマイクロチューブルサブトモグラム分析

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