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Updated: Dec 12, 2025

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

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TREM2 調節は,抗PD-1 免疫療法を強化する腫瘍の骨髄組織を再構成する

Martina Molgora1, Ekaterina Esaulova1, William Vermi2

  • 1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Cell
|August 14, 2020
PubMed
まとめ

TREM2 (骨髄細胞2で発現するトリガリング受容体) をターゲットにすることで,がんの免疫療法を強化することができます. ネズミのTREM2を阻害すると,骨髄細胞群を変化させることで,腫瘍の成長が低下し,抗PD-1治療に対する反応が改善された.

キーワード:
トレム2乳がんチェックポイントの封鎖大腸がん人間マクロファージサルコマ腫瘍

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