リサイクル可能なルイス酸有機触媒としてのROMP-ボラン
Fernando Vidal1, James McQuade1, Roger Lalancette1
1Department of Chemistry, Rutgers University-Newark, 73 Warren Street, Newark, New Jersey 07102, United States.
Journal of the American Chemical Society
|August 14, 2020
まとめ
この研究では,リング開きメタテシスポリメリゼーション (ROMP) を使用したリサイクル可能なアリルボラン・ルイス酸触媒を導入しています. これらの新しいポリマーは,低触媒負荷で効率的な還元性N-アルキレーションを可能にします.
科学分野:
- キャタリシス
- ポリマー化学
- 有機合成
背景:
- アリルボラン・ルイス酸は効果的な触媒ですが,複雑な合成と高負荷の要求により制限があります.
- アリルボランの再生可能で汎用的な触媒システムの開発は,有機化学における重要な課題です.
研究 の 目的:
- リサイクル可能なアリルボラン・ルイス酸触媒を作るための新しいモジュールプラットフォームを開発する.
- 還元性N-アルキル化反応におけるこれらの触媒の有効性を実証する.
主な方法:
- ボランで機能化されたフェニルノルボルネンのリング開きメタテシスポリメリゼーション (ROMP) を利用した.
- 溶解性線形共ポリマーと 交絡性オルガノゲルを合成した
- アリラミンの還元性N-アルキル化における触媒として,生成されたポリマーを使用した.
主要な成果:
- 非常に低い触媒の負荷で高効率の触媒が得られる.
- 優れたコントロールと機能的グループ耐性を示した.
- 溶解性およびクロスリンクされたリサイクル可能なポリマー触媒の両方を成功裏に開発しました.
結論:
- ROMPは,サポートされた有機触媒の設計に多用途でモジュール化されたアプローチを提供します.
- これらの新しいROMP-ボランポリマーは,ルイス酸触媒の効率的でリサイクル可能な代替品を提供します.
- 方法論は様々なトリアリルボランに適応し,サポートされる有機触媒の範囲を拡大します.
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