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Updated: Dec 12, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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リン酸化誘導キメリック小分子

Sachini U Siriwardena1,2, Dhanushka N P Munkanatta Godage1,2, Veronika M Shoba1,2

  • 1Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.

Journal of the American Chemical Society
|August 14, 2020
PubMed
まとめ

リン酸化誘導キメリック小分子 (PHICS) と呼ばれる新しい二機能小分子は,標的タンパク質をリン酸化するためにキナーゼを勧誘することができる. このアプローチにより,研究および治療上の応用のために,タンパク質のリン酸化に対する新しい制御が可能になります.

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