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セリン制限はスフィンゴリピドの多様性を変化させ,腫瘍の成長を抑制する

Thangaselvam Muthusamy1, Thekla Cordes1, Michal K Handzlik1

  • 1Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.

Nature
|August 14, 2020
PubMed
まとめ

毒性デオキシスフィンゴリピドの合成を誘導し,腫瘍の成長を遅らせます. セリン・パルミトイルトランスフェラーゼ (SPT) やフォスフォグリセラート脱水素酶 (PHGDH) を標的とした治療は,新たながん治療戦略を提供する.

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