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Updated: Dec 12, 2025

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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Published on: September 18, 2014

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BAFは,先天的な免疫活性化を防ぐために,核DNAのcGASを制限する

Baptiste Guey1, Marilena Wischnewski1, Alexiane Decout1

  • 1Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland.

Science (New York, N.Y.)
|August 15, 2020
PubMed
まとめ

バリア・トゥ・オートインテグレーション・ファクター1 (BAF) は,サイクリック・グアノシン・モノフォスファート・アデノシン・モノフォスファート・シンテーゼ (cGAS) が自己DNAに結合することを阻害することで,免疫過剰活性化を防ぐ. この発見は 有害な自己炎症反応に対する 細胞の重要な防御を明らかにしています

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