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Updated: Dec 12, 2025

Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein
10:59

Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein

Published on: June 6, 2025

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ATP合成cサブユニット漏れは,脆弱X症候群における異常な細胞代謝を引き起こす

Pawel Licznerski1, Han-A Park2, Harshvardhan Rolyan1

  • 1Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, CT 06511, USA.

Cell
|August 16, 2020
PubMed
まとめ

繊細なX症候群は,シナプスの発達を妨げるミトコンドリアの漏れを伴う. このATP合成のリークチャネルを閉じると 翻訳が正常化し シナプスの成熟が促進され 自閉症の行動が減少する可能性があります

キーワード:
フレージルX症候群自閉症自閉症症候群グリコリスミトコンドリア酸化性リン酸化浸透性のトランジション孔タンパク質合成マウスの繰り返し行動シナプスの発達シナプス可塑性

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