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Updated: Dec 12, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
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Ubiquitin Ligase COP1 マイクログリアでc/EBPβを分解することによって神経炎症を抑制する

Ada Ndoja1, Rohit Reja2, Seung-Hye Lee3

  • 1Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA.

Cell
|August 16, 2020
PubMed
まとめ

通常COP1は マイクログリアの有害な遺伝子活動を抑制します これはアルツハイマー病のような 神経変性における重要な細胞です c/EBPβが蓄積され,神経炎症とタウ病気が悪化する.

キーワード:
C1qCOP1についてタウc/EBPβマイクログリア神経炎症

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