心房細動と認知症
1Department of Medicine, School of Medicine, University of Utah, Salt Lake City.
Circulation
|August 18, 2020
まとめ
心房細動 (AF) は脳 perfusion 問題やその他の要因によって認知症のリスクを高めます. 早期の抗凝固薬とリズム制御は,このリスクを軽減し,さらなる研究が必要である.
科学分野:
- 心臓病科
- 神経学
- ゲロントロジー
背景:
- 心房細動 (AF) は,特に認知症などの有害な併発症と関連しています.
- この関連性は,脳卒中歴のある患者およびそれのない患者において存在します.
研究 の 目的:
- AFと認知症を結びつける 機械的なモデルを探る
- AF患者の認知症リスクを減らすための潜在的な治療戦略を特定する.
主な方法:
- AFと認知症の関連性に関する提案されたメカニズムモデルのレビュー
- 酸化性傷害,炎症,遺伝学などのメディエーターの議論
- 抗凝固剤やリズム/ペース制御などの治療的介入を検討する.
主要な成果:
- 提案されたメカニズムは,脳 perfusion (栓塞性,出血,hyperfusion) の変化を含む.
- 酸化傷害,炎症,自己免疫メカニズム,遺伝子は重要な媒介です
- 抗凝固薬とリズム/速度制御は 治療の潜在的手段です
結論:
- 効果的な抗凝固薬と改善された脳 perfusion 戦略は認知症のリスクを軽減することができます.
- これらの治療アプローチを検証し 認知的成果を測定するために 将来の試験が必要である.
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