神経細胞結合分子 (NCAM) は,細胞と細胞の相互作用を調節する
U Rutishauser1, A Acheson, A K Hall
1Department of Developmental Genetics and Anatomy, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Science (New York, N.Y.)
|April 1, 1988
まとめ
神経細胞粘着分子 (NCAM) は,そのポリシアル酸 (PSA) 含有量を調節することにより,細胞の相互作用を調節します. 低PSAは粘着を強化し,高いPSAは細胞と細胞の接触を阻害し,細胞間通信と軸索誘導に影響を与えます.
科学分野:
- 神経科学は神経科学である.
- 細胞生物学 細胞生物学
- バイオケミストリー バイオケミストリー
背景:
- 神経細胞粘着分子 (NCAM) は,細胞間イベントに不可欠です.
- NCAMは,軸索の誘導,交差点のコミュニケーション,神経伝達物質の酵素レベルに影響を与えます.
研究 の 目的:
- NCAMが特定の分子相互作用のために膜と膜の接触をどのように調節するかを明らかにする.
- NCAM発現とポリシアル酸 (PSA) の含有が細胞粘着を調節する役割を調査する.
主な方法:
- NCAMの表現レベルを分析する.
- NCAMのポリシアル酸 (PSA) 含有量の評価.
- 細胞と細胞の相互作用と膜アポジションに対するNCAMの影響の評価.
主要な成果:
- NCAMは,膜と膜の接触を制御することによって,細胞間イベントを調節する.
- NCAMの低PSA含有量は,細胞粘着を増加させ,接触依存的なイベントを誘発する.
- NCAMの高いPSA含有量は,ステリック障害による細胞間の相互作用を阻害する.
結論:
- NCAMのPSA含有量は,細胞結合と細胞間通信の重要な調節因子である.
- NCAMのPSAレベルを調節することで,神経の発達と機能における細胞間の相互作用を制御するメカニズムが提供されます.
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