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骨髄細胞におけるC9orf72は,STING誘発の炎症を抑制する

Madelyn E McCauley1,2, Jacqueline Gire O'Rourke1,2, Alberto Yáñez3,4

  • 1Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Nature
|August 21, 2020
PubMed
まとめ

骨髄細胞におけるC9orf72の喪失は,STING-インターフェロン経路を過度に活性化することによって,ALS/FTDの炎症を引き起こす. C9-ALS/FTD患者のこの経路を抑制すると,疾患の症状が軽減される可能性があります.

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