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Updated: Dec 11, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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全身性STING活性化非核酸cGAMPミメチックの抗腫瘍活性

Emily N Chin1, Chenguang Yu1,2, Vincent F Vartabedian3

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|August 22, 2020
PubMed
まとめ

研究者らは,小分子刺激因子 (STING) 経路に対するアゴニストであるSR-717を発見した. この化合物は抗腫瘍効果を示し,免疫細胞の活性化を高め,不安定な天然リガンドに有望な代替品を提供します.

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