インスリン調節性組織は,インスリンに敏感な独特のグルコース輸送タンパク質を発現します
D E James1, R Brown, J Navarro
1Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118.
Nature
|May 12, 1988
まとめ
哺乳類の細胞には複数のグルコース輸送システムがあります. この研究は,筋肉と脂肪組織に特異的な,インスリン制御可能なグルコーストランスポータータンパク質を特定し,組織特異のトランスポーターがグルコースの吸収を調節することを示唆しています.
科学分野:
- 細胞生物学 細胞生物学
- 生理学 生理学とは
- バイオケミストリー バイオケミストリー
背景:
- 哺乳類の細胞は,少なくとも3つの異なるグルコース輸送システムを利用しています.
- 第4のシステムであるインスリン依存性キャリアは,筋肉と脂肪組織のために提案されています.
- このトランスポーターは静止細胞の細胞内であり,インスリンに曝露すると表面に移動します.
研究 の 目的:
- 血糖輸送のホルモン調節が組織特有のシグナル伝達またはトランスポーターによるものであるかどうかを調査する.
- 脂肪細胞内のグルコーストランスポーターを特定し,特徴づけること.
主な方法:
- 脂肪細胞のグルコース輸送体に対するモノクローナル抗体の開発.
- 筋肉および脂肪組織におけるグルコース輸送タンパク質の免疫学的識別.
主要な成果:
- モノクローナル抗体は,筋肉と脂肪組織におけるユニークなグルコース輸送タンパク質を特定した.
- このタンパク質はインスリンに調節され,インスリンに依存するグルコース輸送におけるその役割をサポートします.
結論:
- 血糖輸送のホルモン調節は,組織特異的な血糖輸送体によって与えられます.
- ユニークなインスリン調節性グルコーストランスポータータンパク質は,筋肉と脂肪組織に存在します.
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