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Updated: Dec 10, 2025

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ガン SLC43A2はT細胞のメチオニン代謝とヒストンのメチル化を変化させる

Yingjie Bian1,2, Wei Li1,2, Daniel M Kremer3

  • 1Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.

Nature
|September 4, 2020
PubMed
まとめ

腫瘍細胞はメチオニンを消費し,S-アデノシルメチオニン (SAM) を枯渇させ,ヒストンメチレーション (H3K79me2) を減少させ,T細胞の免疫を破壊する. メチオニンのレベルを回復したり,腫瘍のメチオニンの吸収を阻害したりすることで,抗腫瘍T細胞の反応が強化されます.

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