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Updated: Dec 10, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

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定義された構造単位により,小分子結合タンパク質の設計が新たに可能になる

Nicholas F Polizzi1, William F DeGrado1

  • 1Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA. nicholas.polizzi@ucsf.edu william.degrado@ucsf.edu.

Science (New York, N.Y.)
|September 5, 2020
PubMed
まとめ

研究者らは新しいタンパク質設計ユニットである ヴァン・ダー・メル (vdM) を開発し,小さな分子を結合する新しいタンパク質を作成しました. 2つの設計されたタンパク質は,高い親和度で薬剤アピキサバンに結合し,タンパク質エンジニアリングのためのメソッドの可能性を実証しました.

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