ダイエットは小腸微生物群-表皮-免疫ホメオスタシスと腸炎を日常的に調節する
Timur Tuganbaev1, Uria Mor1, Stavros Bashiardes1
1Immunology Department, Weizmann Institute of Science, Rehovot 7610001, Israel.
Cell
|September 5, 2020
まとめ
ダイエットと腸内微生物は 毎日 細腸の免疫を調節します このバランスを,特にMHCクラスIIを乱すと,クローン病を誘発し,新しい介入目標を提供することができます.
科学分野:
- 免疫学
- 胃腸内科
- 微生物学
背景:
- 小腸 (SI) は,食事と微生物による日常的な抗原被曝にもかかわらず,免疫ホメオスタシスを維持します.
- ホメオスタシスの障害は,特に感受性の高い個体では,クローン病の発症に関連しています.
研究 の 目的:
- 食事の含有量とリズムが,微生物群の調節によってSI上皮細胞 (SIEC) の転写環境を調節する方法を調査する.
- SIバリア機能を維持し,クローン型腸炎を予防する食事-微生物-免疫軸の役割を明らかにする.
主な方法:
- 食事と微生物群への反応による昼間のSIEC転写変化の分析
- 昼間の免疫反応を媒介するメジャー・ヒストコンパティビリティ・コンプレックス (MHC) クラスIIの役割を調査する.
- シルカディアン障害,栄養変化,MHCクラスIIの枯渇がSIバリア機能と腸炎に与える影響を評価する.
主要な成果:
- 食事の要因とリズムがSI微生物群を調節し,昼間のSIEC転写環境に影響を与えます.
- SIEC MHCクラスIIの発現は,日中,共生体によって調節され,IL-10+内皮質リンパ球の活動とバリア機能をサポートする.
- この軸の障害は 微生物の流入と クロンのような腸炎を引き起こします
結論:
- SIホメオスタシスを維持するために,昼間の食事-微生物群-MHCクラスII-IL-10-上皮障害軸は不可欠です.
- SI微生物群,免疫,バリア機能を調節する栄養戦略は,クローン病の潜在的な治療目標です.
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