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Updated: Dec 9, 2025

Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae
08:55

Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae

Published on: July 19, 2021

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SLC25A51は哺乳類のミトコンドリアのNAD+トランスポーターである

Timothy S Luongo1, Jared M Eller2, Mu-Jie Lu2

  • 1Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Nature
|September 9, 2020
PubMed
まとめ

哺乳類のミトコンドリアは,エネルギーにとって重要な分子であるニコチナミドアデニン・ディヌクレオチド (NAD+) を輸入することができる. 研究者らはSLC25A51をミトコンドリアのNAD+吸収と細胞呼吸に不可欠なキートランスポーターとして特定した.

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Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
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