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Updated: Dec 9, 2025

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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TRIM37は,PLK4抑制に対する癌特有の脆弱性を制御する

Franz Meitinger1, Midori Ohta2, Kian-Yong Lee2

  • 1Ludwig Institute for Cancer Research, La Jolla, CA, USA. fmeitinger@ucsd.edu.

Nature
|September 10, 2020
PubMed
まとめ

PLK4阻害剤はTRIM37レベルをターゲットにすることで癌を治療することができます. 低TRIM37はPLK4抑制後の癌細胞増殖を助長し,高TRIM37はミトーシス不全を引き起こし,新しい癌治療戦略を提供する.

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