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Updated: Dec 9, 2025

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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cGASの緊密な核結合と不活性化の分子基礎

Baoyu Zhao1, Pengbiao Xu1, Chesley M Rowlett2

  • 1Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.

Nature
|September 10, 2020
PubMed
まとめ

サイクルGMP- AMP合成酵素 (cGAS) は核細胞に結合し,そのDNA感知活性を抑制する. この相互作用は,核の局所化はcGASを不活性状態に保ち,先天的な免疫シグナリングに影響を及ぼすことを説明します.

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