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Updated: Dec 9, 2025

Cell Type-specific Gene Expression Profiling in the Mouse Liver
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Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

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ヒト組織における遺伝子発現の細胞型特異的遺伝子調節

Sarah Kim-Hellmuth1,2,3, François Aguet4, Meritxell Oliva5,6

  • 1Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany. skimhellmuth@gmail.com tlappalainen@nygenome.org.

Science (New York, N.Y.)
|September 11, 2020
PubMed
まとめ

この研究では,ヒトの組織における遺伝的変異の機能的理解を向上させるために,細胞型相互作用量的な特異点 (QTLs) を導入する. これらの新しい細胞型相互作用eQTLは,大量組織分析よりも高い解像度を提供し,以前に隠された遺伝的関連性を明らかにします.

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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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