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Updated: Dec 9, 2025

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
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ミトコンドリアに位置するcircRNAを標的としたSCARは,mROSの出力を減らし,NASHを緩和する

Qiyi Zhao1, Jiayu Liu2, Hong Deng3

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Department of Infectious Diseases, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China; Guangdong Provincial Key Laboratory of Liver Disease Research, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong 510080, China.

Cell
|September 15, 2020
PubMed
まとめ

ミトコンドリア環状RNASCAR (ステアトヘパチス関連サークRNAATP5Bレギュレータ) は,非アルコール性ステアトヘパチス (NASH) で下調調されている. SCARの回復はミトコンドリアのROSを減らし,NASHの進行を緩和し,潜在的な治療目標を提供します.

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