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Updated: Dec 8, 2025

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
11:25

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

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著者 訂正: 初期のマウス胚における系統配分と組織組織の分子構造

Guangdun Peng1,2,3,4, Shengbao Suo5,6, Guizhong Cui7

  • 1State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. peng_guangdun@gibh.ac.cn.

Nature
|September 16, 2020
PubMed
まとめ

この研究は修正された. 最新の発見と訂正については,更新版を参照してください.

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Methods for Precisely Localized Transfer of Cells or DNA into Early Postimplantation Mouse Embryos

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関連する概念動画

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
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Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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