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The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies
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brlAは,アスペルギルス・ニドゥランスにおけるコンディオフォア発育を誘導するために必要かつ十分である
T H Adams1, M T Boylan, W E Timberlake
1Department of Genetics, University of Georgia, Athens 30602.
Cell
|July 29, 1988
まとめ
brlA遺伝子はAspergillus nidulansの発達を調節し,細胞を成長から胞子形成に切り替えます. 植物性細胞におけるその発現は,特定の遺伝子を活性化することによって,胞子化を誘発する.
科学分野:
- 分子生物学は分子生物学である.
- 発達生物学 発達生物学とは
- 菌類学 菌類学とは
背景:
- Aspergillus nidulans の brlA 遺伝子は,植物の成長からコンディオフォアの発達への移行を制御する.
- brlAは,Xenopus TFIIIAのDNA結合モチーフに似たタンパク質をコードする.
研究 の 目的:
- A. nidulans. の発達移行を媒介する brlA 遺伝子の役割を調査する.
- 胞子形成中の遺伝子発現を調節するBRLAタンパク質の機能を理解する.
主な方法:
- 遺伝子発現パターンの分析.
- 細胞形態と発達変化の観察.
- brlA発現の遺伝子操作. brlA発現の遺伝子操作. brlA発現の遺伝子操作. brlA発現の遺伝子操作. brlA発現の遺伝子操作. brlA発現の遺伝子操作.
主要な成果:
- 植生性細胞におけるBrlA発現の誤ったスケジュールにより,発育性遺伝子の転写活性化が誘発された.
- brlA発現は,ヒファの成長の停止とコンディオフォアのような構造の開始につながった.
- 生存可能なコンディオスポアは,植物性細胞におけるBRlA発現によって生成された.
結論:
- BRLAタンパク質は,核酸結合タンパク質であると提案されています.
- 植物性細胞における brlA の発現は,胞子形成を誘発するのに十分である.
- BRLAは,コンディション特有の遺伝子の発現を調節し,発達スイッチを制御します.
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