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Updated: Dec 7, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
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Published on: December 23, 2020

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SARS-CoV-2 感染症は細胞ヘパラン硫酸塩と ACE2 に依存する

Thomas Mandel Clausen1, Daniel R Sandoval2, Charlotte B Spliid1

  • 1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Infectious Disease, Copenhagen University Hospital, 2200 Copenhagen, Denmark.

Cell
|September 24, 2020
PubMed
まとめ

SARS-CoV-2のスパイクタンパク質は,ACE2への結合を強化するために細胞ヘパラン硫酸を使用し,ウイルス感染を促進します. ヘパリンと関連する分子は この相互作用を阻害し 新しい治療戦略を提供できます

キーワード:
コロナウイルスSARS-CoV-2についてコロナウイルスヘパラン硫酸ヘパラン硫酸結合タンパク質ヘパリン肺上皮細胞偽型ウイルススパイクタンパク質

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