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N4BP1のカスパース-8分裂による先天性免疫信号の統合

Alexander D Gitlin1,2, Klaus Heger3, Alexander F Schubert4

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. adgitlin@stanford.edu.

Nature
|September 24, 2020
PubMed
まとめ

NEDD4結合タンパク質1 (N4BP1) は,サイトカインの産生を抑制し,カスパース8によって不活性化されます. カスパース-8による分裂は炎症信号を統合し,カスパース-8変異に関連した免疫不全を説明します.

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