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Updated: Dec 7, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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C2 Enantioselective [4 + 1]-Cycloadditionsのための対称なディニッケル触媒

Michael J Behlen1, Christopher Uyeda1

  • 1Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Journal of the American Chemical Society
|September 25, 2020
PubMed
まとめ

ディニッケル触媒は非対称 [4 + 1] - サイクロアディションを可能にし,高いZ-アルケンの選択性を持つメチレンサイクロペンテンを生成します. この方法はステレオコンバージェントであり,効率的な合成のためにE/Z-ダイエンの混合を可能にします.

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The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
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