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Updated: Dec 7, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

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リピート・エクスパンションは,マイクロサテライト不安定がんにおいてWRN依存性を与える

Niek van Wietmarschen1, Sriram Sridharan1, William J Nathan1,2

  • 1Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Nature
|October 1, 2020
PubMed
まとめ

WRNヘリケーゼは,微小衛星不安定性 (MSI) がんをDNA破裂から保護する. MSI細胞の拡張されたTAリピートは複製を停止し,染色体の破裂を防ぐためにWRNを必要とします.

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