Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.7K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.7K
Adherens Junctions01:24

Adherens Junctions

5.7K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
5.7K
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

3.1K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
3.1K
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

3.3K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
3.3K
Anchoring Junctions01:03

Anchoring Junctions

4.5K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
4.5K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

8.5K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
8.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Active and probe-free intracellular rheology via phase-sensitive thermoviscous flows.

PNAS nexus·2026
Same author

Keratins coordinate tissue spreading by balancing spreading forces with tissue material properties.

Nature communications·2026
Same author

Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors.

eLife·2026
Same author

Structural insights into the Thermus thermophilus type IV pilus machinery assembling two distinct pili.

Communications biology·2026
Same author

Tissue Fluidity Mediates a Trade-off Between the Speed and Accuracy of Multicellular Patterning by Cell Sorting.

bioRxiv : the preprint server for biology·2025
Same author

A Knock-in Zebrafish Reporter Line for Live Visualization of Endogenous Olig2 Protein Dynamics.

Zebrafish·2025
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
関連記事をすべて見る

関連する実験動画

Updated: Dec 7, 2025

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
12:26

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

6.2K

粘着コードは,組織形態変異の間に堅固なパターン形成を保証する.

Tony Y-C Tsai1, Mateusz Sikora2, Peng Xia2

  • 1Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston MA 02115, USA.

Science (New York, N.Y.)
|October 2, 2020
PubMed
まとめ
この要約は機械生成です。

ゼブラフィッシュのニューラルプロジェニター細胞は,カデリン発現とソニック・ヘッジホッグ・シグナルによって誘導される 微分細胞結合によって堅固なパターンを形成する. この相互作用は 細胞の再編成にもかかわらず 正確な組織発達を保証します

さらに関連する動画

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
10:04

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Published on: September 28, 2019

8.7K
Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

4.5K

関連する実験動画

Last Updated: Dec 7, 2025

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
12:26

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

6.2K
Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
10:04

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Published on: September 28, 2019

8.7K
Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

4.5K

科学分野:

  • 発達生物学
  • 細胞生物学
  • 神経科学

背景:

  • 動物の発達には 細胞の正確な空間的および時間的な組織が必要です
  • 頑丈なパターンの形成は不可欠です 特にゼブラフィッシュの発達中の脊髄のような ダイナミックな環境では
  • ニューラルプロジェニターは,変数形質シグナル伝達と細胞の動きにもかかわらず,ステレオタイプパターンを確立しなければなりません.

研究 の 目的:

  • 斑馬魚の脊髄における 頑丈な神経原始体の仕組みを調査する
  • 細胞分類と組織組織を媒介する差分粘着モデルの証拠を提供する.
  • この過程における特定のカデリンとモルフォゲン・グラディエントの役割を明らかにする.

主な方法:

  • 3つの内生性ニューラルプロジェニータの粘着力と好みを直接測定する.
  • カデリン (N-カデリン,カデリン11,プロトカデリン19) の細胞型特異的結合表現の分析
  • ソニック・ヘッジホッグ・モルフォゲン・グラデントによる差分粘着コードの調節に関する調査.

主要な成果:

  • 細胞間粘着の差異は細胞分類を媒介し,差異的粘着モデルを支持する.
  • カデリンの結合表現は,ex vivoの同型偏好とin vivoの堅固なパターンを導きます.
  • 微分粘着コードはソニック・ヘッジホッグ・モルフォゲン・グラデントによって制御される.

結論:

  • 特定のカデリン結合によって媒介される差分結合は,堅固なニューラルプロジェニターパターニングの重要なメカニズムである.
  • 粘着に基づく自己組織と形態素誘導パターンの相互作用は,堅固な組織形態変異を保証する.
  • この研究は,ゼブラフィッシュの脊髄における 細胞粘着が発達パターンの強さにどのように貢献するかを明らかにしています.