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Updated: Dec 7, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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Published on: January 2, 2015

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オートソーム支配的VCPの低形変異はPHF-tauの分解を阻害する

Nabil F Darwich1, Jessica M Phan1, Boram Kim1

  • 1Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.

Science (New York, N.Y.)
|October 2, 2020
PubMed
まとめ

バロシンを含むタンパク質 (VCP) の遺伝的変異は,タウ分裂を阻害し,神経線維の絡みや認知症を引き起こす. このVCP変異は,アルツハイマー病および関連するタオパシーに対する潜在的な治療目標を提供します.

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