Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

4.2K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
4.2K
Mitochondrial Membranes01:45

Mitochondrial Membranes

15.7K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
15.7K
Mitochondria01:37

Mitochondria

18.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
18.5K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

8.7K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
8.7K
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

10.8K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
10.8K
Mitochondrial Protein Sorting01:39

Mitochondrial Protein Sorting

5.4K
Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
Most of these mitochondrial proteins are encoded by the nucleus and imported to the mitochondria as unfolded or loosely folded precursors. Mitochondrial precursors...
5.4K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Generation of precise and accurate engineered circRNAs using enzymatic ligation.

Nucleic acids research·2026
Same author

HIV-1-encoded circular RNA enhances viral transcription through Tat binding.

Nature microbiology·2026
Same author

Publisher Correction: Discovery and biological characterization of geranylated RNA in bacteria.

Nature chemical biology·2025
Same author

Coronavirus NSP14 Drives Internal m <sup>7</sup> G Modification to Rewire Host Splicing and Promote Viral Replication.

bioRxiv : the preprint server for biology·2025
Same author

The ERVK3-1 Microprotein Interacts with the HUSH Complex.

Biochemistry·2025
Same author

Human and pathogen-encoded circular RNAs in viral infections: insights into functions and therapeutic opportunities.

Human molecular genetics·2025

関連する実験動画

Updated: Dec 7, 2025

Discrimintion and Mapping of the Primary and Processed Transcripts in Maize Mitochondrion Using a Circular RT-PCR-based Strategy
07:26

Discrimintion and Mapping of the Primary and Processed Transcripts in Maize Mitochondrion Using a Circular RT-PCR-based Strategy

Published on: July 29, 2019

6.4K

すべて を 支配 する 一つ の 環:ミトコンドリア の 円形 の RNA が ミトコンドリア の 機能 を 制御 する

Lichong Yan1, Y Grace Chen1

  • 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Cell
|October 2, 2020
PubMed
まとめ

ミトコンドリアの円形RNA (circRNAs) は,ATP合成酵素β (ATP5B) と相互作用することで,肝疾患を調節する. この相互作用は,ミトコンドリアの活性酸素種と肝臓の線維細胞の活性化を阻害し,病気の病原性に関する新しい洞察をもたらします.

科学分野:

  • ミトコンドリア生物学
  • RNA生物学
  • セルラー信号

背景:

  • 循環型RNA (circRNAs) は,生物学的過程における重要な調節因子として認識されている.
  • ミトコンドリアDNAによって暗号化されたcircRNAの特異的な機能は,ほとんど未知のままである.
  • ミトコンドリア機能障害は,肝臓疾患を含む様々な疾患に関連しています.

研究 の 目的:

  • 生物学的調節におけるミトコンドリアのcircRNAの役割とメカニズムを調査する.
  • ミトコンドリアDNAでコードされたcircRNAの特定の相互作用と機能を特定する.
  • 肝疾患の病原性におけるミトコンドリアのcircRNAsの関与を明らかにする.

主な方法:

  • ミトコンドリアDNAにコードされた円形RNAの分析
  • サークRNAとミトコンドリアのタンパク質,特にATP合成亜単位β (ATP5B) の相互作用の調査.
  • ミトコンドリアの活性酸素種 (ROS) 生成と肝臓の線維細胞活性化の評価

主要な成果:

  • ミトコンドリアDNAでコードされたcircRNAは,ATP合成亜単位β (ATP5B) と相互作用することが判明した.
  • この相互作用は,ミトコンドリアの活性酸素種 (ROS) の生成を効果的に抑制する.

さらに関連する動画

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research
09:53

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research

Published on: June 7, 2024

1.4K
Studying Mitochondrial Structure and Function in Drosophila Ovaries
09:53

Studying Mitochondrial Structure and Function in Drosophila Ovaries

Published on: January 4, 2017

24.6K

関連する実験動画

Last Updated: Dec 7, 2025

Discrimintion and Mapping of the Primary and Processed Transcripts in Maize Mitochondrion Using a Circular RT-PCR-based Strategy
07:26

Discrimintion and Mapping of the Primary and Processed Transcripts in Maize Mitochondrion Using a Circular RT-PCR-based Strategy

Published on: July 29, 2019

6.4K
Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research
09:53

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research

Published on: June 7, 2024

1.4K
Studying Mitochondrial Structure and Function in Drosophila Ovaries
09:53

Studying Mitochondrial Structure and Function in Drosophila Ovaries

Published on: January 4, 2017

24.6K
  • 肝臓疾患における重要なプロセスである肝臓線維芽細胞の活性化も抑制する.

    • 結論:

    • ミトコンドリアのcircRNAは,重要なミトコンドリアの成分と相互作用することで,細胞のプロセスにおいて重要な役割を果たします.
    • circRNAs,ATP5B,ROS,および線維細胞の活性化を含む同定されたメカニズムは,肝臓疾患の病原性を調節する新しい経路を提供します.
    • これらの発見は,ミトコンドリアのcircRNA機能をターゲットにすることで,肝疾患を理解し,潜在的に治療するための新しい道を開きます.