関連する実験動画

Updated: Dec 7, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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RGSタンパク質によるGタンパク質シグナル伝達制御のグローバルマップ

Ikuo Masuho1, Santhanam Balaji2, Brian S Muntean1

  • 1Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33458, USA.

Cell
|October 2, 2020
PubMed
まとめ

Gタンパク質シグナル伝達レギュレータ (RGS) は,Gαサブユニットを無効化することによって,Gタンパク質シグナル伝達を制御する. この研究は,RGS-Gαの認識と選択性を支配するルールを明らかにし,分子認識の原則を前進させる.

キーワード:
BRET についてGタンパク質GPCR についてRGS祖先の復元セル信号遺伝的変異タンパク質とタンパク質の相互作用ストライタム

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