関連する実験動画

Updated: Dec 6, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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核酸の構造と機能の熱可逆制御

Steve D Knutson1, Aimee A Sanford1, Colin S Swenson1

  • 1Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.

Journal of the American Chemical Society
|October 5, 2020
PubMed
まとめ

グリオキサルの改変により,様々な核酸の可逆的な熱制御が可能になり,治療薬とバイオコンピューティングでの応用が可能です. この方法はPCRの特異性を高め,生細胞における遺伝子発現を制御します.

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