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聴覚皮質における母子の行動に対する先天的および可塑的メカニズム
Jennifer K Schiavo1,2,3,4, Silvana Valtcheva1,2,3,4, Chloe J Bair-Marshall1,2,3,4
1Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, USA.
Nature
|October 8, 2020
まとめ
両親の動物は 聴覚皮質の 経験に依存した可塑性を通して 赤ちゃんの緊急呼び出しを 認識することを学びます この神経可塑性により 声の多様性に対する反応が一般化され 信頼性の高い育児行動が保証されます
科学分野:
- 神経科学
- 動物 の 行動
- 聴覚処理
背景:
- 赤ちゃん の 声 に 反応 する よう 学ぶ 仕組み は,まだ 完全 に 理解 さ れ て い ませ ん.
- 赤ちゃんの泣き声は 親の強い反応を誘発しますが この敏感さが生まれつきなのか 学習されたのか は不明です
研究 の 目的:
- 聴覚皮質における内在的なメカニズムと経験依存の可塑性の役割について,マウスの母性行動の発生について調査する.
- 脳の聴覚処理が 変化する赤ちゃんの救急呼び出しに 適応する仕組みを理解するためです
主な方法:
- 幼虫の緊急呼び出しに対する神経的および行動的反応を,天真で経験豊富な (同棲) メスマウスで研究した.
- 音声統計を操作し 神経可塑性を評価するために 合成呼び出しを使用しました
- 皮質の活動と 視床下部のオキシトシン系を研究した
主要な成果:
- ネイブマウスはプロトタイプの救急呼び出し間隔に敏感で,母性マウスはより広い範囲で反応を一般化しました.
- 聴覚皮質の神経反応は 経験依存の可塑性を示し 興奮は拡大し 抑制は鋭化しました
- 神経行動反応は 合成呼び出し統計に適応し 皮質の活動とオキシトシンが必要です
結論:
- 母親の行動の発症は,内在的な聴覚の感度と経験主導の皮質の可塑性との相互作用によるものです.
- 聴覚皮質の神経可塑性メカニズムは 信頼性の高い育児に迅速な適応を可能にします
- 経験によって 聴覚処理が精進し 幼児の発声に 適切な反応が得られます
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