の ゲノム は,適応 的 な 異性 性 に 関連 し て いる 制御 的 な 調整 を 示し て い ます
Francisca M Real1,2, Stefan A Haas3, Paolo Franchini4
1RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Science (New York, N.Y.)
|October 9, 2020
まとめ
女性モールのゲノム再編は 卵巣の男性化を説明します この研究は 遺伝子の調節の変化が 哺乳類の独特な性発達に 影響を及ぼすことを明らかにしています
科学分野:
- 進化 的 な 遺伝子
- ゲノミクス
- 哺乳類の繁殖
背景:
- ゲノム変異をフェノタイプの特徴と結びつけることは,進化遺伝学の重要な課題です.
- 哺乳類は多様な生殖戦略を示し,いくつかの種は独特の性的発達パターンを示しています.
研究 の 目的:
- 雌イベリアンモール (Talpa occidentalis) の卵巣を男性化させる遺伝的根拠を調査する.
- この種の性発達の変化を 引き起こしたゲノムの再編成と 規制の変化を特定する.
主な方法:
- クロモソームスケールゲノムアセンブリを用いた系統分析.
- トランスクリプトミック,エピジェネティック,およびクロマチン相互作用データの統合.
- トランスジェニックマウスモデルを用いた機能的検証
主要な成果:
- CYP17A1 (アンドロゲン合成遺伝子) のタンデムトリプリケーションとFGF9 (プロテストキュラー遺伝子) の逆転が確認されました.
- これらの再編成は,性器の発達に関与する遺伝子の規制の様子を変化させます.
- これらの遺伝的変化を模倣したトランス遺伝子マウスは 男性化現象を示した.
結論:
- 統合的ゲノムアプローチは,非コーディング配列の変化が現象進化に与える影響を明らかにすることができます.
- Talpa occidentalisの特定のゲノム再編成は,男性化卵巣の発達に起因する.
- この研究は,哺乳類の性発達と進化の基礎にある遺伝的メカニズムについての洞察を提供します.
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