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関連する概念動画

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

391
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
391
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

590
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
590
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.3K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.3K
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

502
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
502
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

964
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
964
Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

933
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
933

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関連する実験動画

Updated: Dec 6, 2025

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
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The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

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機能性消化不全

Alexander C Ford1, Sanjiv Mahadeva2, M Florencia Carbone3

  • 1Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Leeds Gastroenterology Institute, St James's University Hospital, Leeds, UK.

Lancet (London, England)
|October 13, 2020
PubMed
まとめ
この要約は機械生成です。

機能性消化不良は,健康な人の16%に影響し,明確な構造的な原因のない腹部上部の症状を伴う. 治療は不完全な理解のために困難ですが,ヘリコバクター・パイロリ根絶と他の治療法は有望です.

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Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
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Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

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関連する実験動画

Last Updated: Dec 6, 2025

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
06:40

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

Published on: June 29, 2019

6.9K
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

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Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
05:36

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

Published on: October 4, 2024

931

科学分野:

  • 胃腸内科
  • 機能的胃腸疾患

背景:

  • 消化不良は 腹部上部の痛みや灼熱,満腹感,早めの飽き飽きといった症状を含みます.
  • 機能性消化不全 (FD) は一般人口の16%まで発生し,80%の症例では構造的な説明がない.
  • FDの危険因子には,心理的な問題,H. pylori感染,NSAIDの使用,喫煙,女性の性別が含まれます.

研究 の 目的:

  • 機能性消化不全の現在の理解,その病理生理学,診断,管理をレビューする.
  • FDの複雑で不完全なメカニズムによる治療における課題を強調する.

主な方法:

  • 機能性消化不全の病理学,危険因子,診断方法,治療選択肢に関する文献レビュー.
  • 根絶療法,酸抑制剤,プロキネティック,神経調節剤を含む様々な治療方法に関する現在の証拠の分析.

主要な成果:

  • FDの病理生理学は多因性であり,腸-脳軸機能不全があり,運動能力の問題,内臓過敏症,および微生物群の変化につながる.
  • エンドスコピーの効用はFDでは限られており,主に高齢の患者 (> 55) または警報機能を有する患者に対して推奨されます.
  • いくつかの治療法は,H. pyloriの根絶,PPI,H2RA,プロキネティクス,中央神経調節剤を含む有効性を示しているが,心理学的治療法の役割は不明である.

結論:

  • 機能性消化不良は,症状が変動する慢性疾患であり,病理学的理解が不完全であるため,しばしば治療が困難である.
  • 陽性な患者にはH. pyloriの根絶が推奨されます. 将来の研究で 病気を修正する治療法が得られるかもしれません