刺激性腸症候群
Alexander C Ford1, Ami D Sperber2, Maura Corsetti3
1Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Leeds Gastroenterology Institute, St James's University Hospital, Leeds, UK.
Lancet (London, England)
|October 13, 2020
まとめ
刺激性腸症候群 (IBS) は,腹痛と腸の習慣の変化を特徴とする一般的な機能的胃腸疾患です. 腸-脳軸の病理生理学を理解することで 患者の治療結果を改善する 標的型治療法を開発できます
科学分野:
- 胃腸内科
- 神経胃腸内科
- 機能的胃腸疾患
背景:
- 刺激性腸症候群 (IBS) は,5-10%の健康な個人に影響し,腹痛と便の形態/頻度の変化を示します.
- 危険因子には腸内感染症,心理的な併発症,若い女性の高い罹患率が含まれます.
- 病理生理学には 腸-脳軸の機能不全があり 運動能力の問題や 内臓過敏症や 中枢神経系の処理が変化します
研究 の 目的:
- 刺激性腸症候群 (IBS) の病理生理学に関する現在の理解をレビューする.
- IBSの診断方法と管理戦略を概説する.
- IBSの新たな治療法の発展を強調する.
主な方法:
- IBSの病理生理学,診断,治療に関する既存の文献のレビュー.
- 危険因子と疫学データの分析
- 現在の治療法と新しい治療法の検討
主要な成果:
- IBSの診断は 病歴に依拠し 警報症状を慎重に調べます
- 管理は患者の教育,食事の変更,繊維,抗薬に焦点を当てています.
- 先進的な治療は,神経調節薬,受容体特異薬,心理療法を用いて重症症状を標的としています.
結論:
- 効果的なIBS管理には 共感的なアプローチが必要で 生活の質を向上させ 医療費を削減します
- 腸-脳軸はIBSの病理生理学の中心であり,進行中の研究により新しい薬候補が得られます.
- 最近の病理学的洞察に基づいて,新しいIBS治療法のパイプラインが増加すると予想されています.
関連する概念動画
01:17Irritable Bowel Syndrome I: Introduction
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
755
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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01:30Irritable Bowel Syndrome III: Medical and Nursing Management
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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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01:17Chronic Bowel Disorders: Introduction
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
663
01:17Drugs for Treatment of Diarrhea-Predominant IBS
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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
479
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
664